Chronisch-entz\u00fcndliche Parodontalerkrankungen sind keineswegs auf die Mundh\u00f6hle allein beschr\u00e4nkt \u2013 sie k\u00f6nnen ernstzunehmende Gesundheitsrisiken darstellen. Zahlreiche Studien liefern zunehmend Hinweise auf die systemischen Zusammenh\u00e4nge zwischen Parodontitis und allgemeinem Gesundheitszustand.<\/span><\/p>\n Besonders gut wurde die Verkn\u00fcpfung von Parodontitis und Diabetes mellitus untersucht. Zwischen diesen beiden weit verbreiteten Erkrankungen besteht eine bidirektionale negative Beziehung. Bei Diabetikern ist das Parodontitisrisiko dreimal h\u00f6her als bei Nichtdiabetikern.<\/span><\/p>\n Umgekehrt beeintr\u00e4chtigt eine manifeste Parodontitis den Stoffwechsel von Diabetikern und erh\u00f6ht damit das Risiko von Diabetes-assoziierten Komplikationen.<\/span><\/p>\n Dar\u00fcber hinaus zeigen Beobachtungsstudien, dass Menschen, die an einer Parodontitis leiden, ein signifikant h\u00f6heres Risiko f\u00fcr Herz-Kreislauf-Erkrankungen wie Myokardinfarkt (Herzinfarkt) tragen. Zahlreiche Studien liefern Hinweise auf einen Zusammenhang zwischen Parodontalerkrankungen und Krebs, rheumatoider Arthritis, Osteoporose, chronischen Atemwegserkrankungen, sowie unterschiedlichen Belastungen f\u00fcr gesunde Menschen, u.a. Senioren, Rauchern und Frauen mit Kinderwunsch.<\/span><\/p>\n Einige systemische Krankheiten die mit oralen Entz\u00fcndungen assoziiert sein k\u00f6nnen<\/span><\/p>\n Zu den Risikofaktoren, die orale Entz\u00fcndungen f\u00f6rdern k\u00f6nnen, geh\u00f6ren\u00a0<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dipi_carousel navigation=”on” navigation_on_hover=”on” navigation_prev_icon_yn=”on” navigation_prev_icon=”4||divi||400″ navigation_next_icon_yn=”on” navigation_next_icon=”5||divi||400″ navigation_size=”20″ navigation_padding=”20″ navigation_color=”#FFFFFF” navigation_bg_color=”#FE5E15″ navigation_circle=”on” navigation_position_right=”-40px” columns_tablet=”2″ columns_phone=”1″ columns_last_edited=”on|tablet” navigation_position_left_tablet=”-40px” navigation_position_left_phone=”-25px” navigation_position_left_last_edited=”on|tablet” navigation_position_right_tablet=”-40px” navigation_position_right_phone=”-25px” navigation_position_right_last_edited=”on|tablet” _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][dipi_carousel_child title_text=”Implant Safe Center” desc_text=”<\/p>\n Pellentesque tincidunt text of the elit dapibus lacus sodales dummy sed industry<\/p>\n ” img_width=”64px” _builder_version=”4.20.4″ _module_preset=”default” title_font=”|600|||||||” title_font_size=”18px” desc_line_height=”2em” background_color=”#F5F5F5″ background_enable_color=”on” custom_padding=”20px||20px||true|false” global_colors_info=”{}”][\/dipi_carousel_child][dipi_carousel_child title_text=”Oral Fitness Coach” desc_text=”<\/p>\n Pellentesque tincidunt text of the elit dapibus lacus sodales dummy sed industry<\/p>\n ” img_width=”64px” _builder_version=”4.20.4″ _module_preset=”default” title_font=”|600|||||||” title_font_size=”18px” desc_line_height=”2em” background_color=”#F5F5F5″ background_enable_color=”on” custom_padding=”20px||20px||true|false” global_colors_info=”{}”][\/dipi_carousel_child][dipi_carousel_child title_text=”Oral Fitness Center” desc_text=”<\/p>\n Pellentesque tincidunt text of the elit dapibus lacus sodales dummy sed industry<\/p>\n ” img_width=”64px” _builder_version=”4.20.4″ _module_preset=”default” title_font=”|600|||||||” title_font_size=”18px” desc_line_height=”2em” background_color=”#F5F5F5″ background_enable_color=”on” custom_padding=”20px||20px||true|false” global_colors_info=”{}”][\/dipi_carousel_child][dipi_carousel_child title_text=”G\u00fctesiegel” desc_text=”<\/p>\n Pellentesque tincidunt text of the elit dapibus lacus sodales dummy sed industry<\/p>\n ” img_width=”64px” _builder_version=”4.20.4″ _module_preset=”default” title_font=”|600|||||||” title_font_size=”18px” desc_line_height=”2em” background_color=”#F5F5F5″ background_enable_color=”on” custom_padding=”20px||20px||true|false” global_colors_info=”{}”][\/dipi_carousel_child][\/dipi_carousel][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Matrix-Metalloproteinasen (MMP) kommen \u00fcberall in menschlichen Geweben vor. Die Enzyme erf\u00fcllen wichtige Aufgaben bei physiologischen Auf- und Umbauprozessen, z.B. bei der Wundheilung, indem sie den Abbau von Kollagenen und Elastin in der Haut katalysieren. Auch bei zahlreichen pathologischen Vorg\u00e4ngen sind MMP beteiligt, u.a. bei Herz-Kreislauf-Erkrankungen, Arthritis, Tumoren und Parodontitis.<\/span><\/p>\n Die k\u00f6rpereigene Matrix-Metalloproteinase-8 (MMP-8) und ihre Freisetzung werden durch parodontale Bakterien induziert. In der aktiven Form gilt aMMP-8 als eine der wichtigsten destruktiven Enzyme bei Parodontalerkrankungen. Sie ist als einziges Enzym der MMP-Familie in der Lage, sowohl Typ-I- als auch Typ-III-Kollagen zu spalten und f\u00fcr den Abbau des dreidimensionalen Kollagennetzwerks des Parodontiums verantwortlich. aMMP-8 ist in hohem Ma\u00dfe mit der Schwere der parodontalen Entz\u00fcndung assoziiert und somit bei der Parodontitis und Periimplantitis als fr\u00fcher Biomarker zu sehen.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n Neuere Studien zeigen einen Zusammenhang von aMMP-8 mit dem Auftreten systemischer Erkrankungen: So ist die MMP-8-Serumkonzentration assoziiert mit dem Risiko f\u00fcr koronare Ereignisse, Herzinfarkt und Mortalit\u00e4t (Kormi 2017). Es gibt Hinweise auf eine Korrelation der MMP-8-Konzentration mit der Prognose bei Darmkrebs (B\u00f6ckelman et al. 2018) und bei Magenkrebs (Laitinen et al. 2018).<\/span><\/p>\n M\u00f6glicherweise kann aMMP-8 als Biomarker f\u00fcr die Risikobeurteilung systemischer Erkrankungen herangezogen werden.\u00a0<\/span><\/p>\n Vor diesem Hintergrund k\u00f6nnen Verfahren zur Fr\u00fcherkennung und Diagnose von Parodontalerkrankungen, die auf eine geeignete Behandlung hinauslaufen, bei der Senkung des systemischen Gesundheitsrisiken eine bedeutende Rolle zukommen.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_text][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Mit den aMMP-8-Testsystemen von Dentognostics f\u00fcr Zahnmediziner kann die aMMP-Konzentration im Speichel bzw. in der Sulkusfl\u00fcssigkeit (GCF\/PISF) qualitativ oder quantitativ bestimmt werden. Auf diese Weise ist es m\u00f6glich, parodontalen, kollagenolytischen Kollagenabbau nachzuweisen, selbst wenn noch keine Anzeichen daf\u00fcr im R\u00f6ntgen oder bei der Sondierung (Bleeding on Probing; BOP) erkennbar sind. So l\u00e4sst sich der dynamische Prozess des aktiven oralen Kollagenabbaus belegen und \u2013 was noch interessanter ist \u2013 die zuk\u00fcnftige Entwicklung und das Progressionsrisiko prognostizieren (Sorsa et al. 2010, 2016, 2018).<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” padding_top_2=”50px” padding_right_2=”50px” padding_bottom_2=”50px” padding_left_2=”50px” padding_top_bottom_link_2=”true” padding_left_right_link_2=”true” padding_2_tablet=”” padding_2_phone=”30px|20px|30px|20px|true|true” padding_2_last_edited=”on|phone” custom_css_main_2=”box-shadow: 0px 2px 18px 0px rgb(100 130 208 \/ 17%);” _builder_version=”4.20.4″ _module_preset=”default” custom_padding=”58px|||||” global_colors_info=”{}”][et_pb_column type=”1_2″ specialty_columns=”2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dipi_dual_heading first_heading=”von den Vorteilen profitieren” use_background_text=”on” background_text=”Dabei sein” fh_padding=”0px|10px|0px|10px|false|true” bt_position_vertical=”25%” bt_style=”stroke” bt_stroke_color=”#e9ecef” bt_stroke_fill=”RGBA(255,255,255,0)” background_text_color_gradient_direction=”90deg” background_text_color_gradient_stops=”#00235a 0%|#7d8aa1 100%” background_text_color_gradient_start=”#00235a” background_text_color_gradient_end=”#7d8aa1″ bt_padding=”0px|0px|0px||false|false” bt_margin=”|0px|0px|10px|false|false” _builder_version=”4.20.4″ _module_preset=”default” first_heading_text_color=”#FE5E15″ first_heading_font_size=”14px” first_heading_letter_spacing=”3px” background_text_font=”|||on|||||” background_text_text_align=”left” background_text_font_size=”80px” text_orientation=”left” custom_margin=”||||false|false” background_text_font_size_tablet=”80px” background_text_font_size_phone=”50px” background_text_font_size_last_edited=”on|phone” background_text_line_height_phone=”2.6em” background_text_line_height_last_edited=”off|phone” custom_css_main_element=”margin-bottom: 25px !important;” border_color_left=”#FE5E15″ border_width_left_bt_border=”5px” locked=”off” global_colors_info=”{}” background_text_text_color__hover_enabled=”off|desktop” overlay_bg_color_gradient_type_tablet=”linear” overlay_bg_color_gradient_type_phone=”linear” overlay_bg_color_gradient_type__hover=”linear” image_bg_color_gradient_type__hover=”linear”][\/dipi_dual_heading][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” header_2_font=”|700|||||||” header_2_font_size=”35px” header_2_line_height=”1.5em” custom_margin=”||10px||false|false” header_2_font_size_tablet=”35px” header_2_font_size_phone=”28px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.22.1″ _module_preset=”default” locked=”off” global_colors_info=”{}”]<\/p>\n Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. 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global_colors_info=”{}”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Science\n
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Interdisziplin\u00e4re Diagnostik und Zusammenarbeit<\/span><\/h5>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
aMMP-8 das Bindeglied zwischen parodontalen-<\/span><\/h3>\n<\/div>\n<\/div>\n
und\u00a0<\/span>systemischen Erkrankungen<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
Gesunder Mund \u2013 Gesunder K\u00f6rper<\/span><\/h5>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
aMMP-8 zur Fr\u00fcherkennung und Progressionsmessung<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
F\u00f6rdermitglied werden<\/h2>\n